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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Flavokawain A, Herceptin
Phytochemical Name Flavokawain A (PubChem CID: 5355469 )
Anticancer drug Name Herceptin (PubChem CID: / )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 134
Ref_1
Pair Name Flavokawain A, Herceptin
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression BCL2L11 KEGG ID N.A.
Down-regulation Expression BCL-xL hsa598
Up-regulation Expression BIM hsa10018
Down-regulation Phosphorylation CDC25C hsa995
Down-regulation Phosphorylation CDK1 hsa983
Down-regulation Expression ERBB2 hsa2064
Down-regulation Expression ERBB2 hsa2064
Down-regulation Expression MYT1 hsa4661
Down-regulation Expression SKP2 hsa6502
Down-regulation Expression WEE1 hsa7465
Down-regulation Expression XIAP hsa331
In Vitro Model MCF-7 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0031
MDA-MB-468 Breast adenocarcinoma Homo sapiens (Human) CVCL_0419
Result Our results suggest FKA as a promising and novel apoptosis inducer and G2 blocking agent that, in combination with Herceptin, enhances for the treatment of HER2-overexpressing breast cancer.
03. Reference
No. Title Href
1 Induction of G2M Arrest by Flavokawain A, a Kava Chalcone, Increases the Responsiveness of HER2-Overexpressing Breast Cancer Cells to Herceptin. Molecules. 2017 Mar 14;22(3):462. doi: 10.3390/molecules22030462. Click
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